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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Updated: May 18, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

Going beyond EGFR.

S Zimmermann1, S Peters

  • 1Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|September 19, 2012
PubMed
Summary
This summary is machine-generated.

Targeting specific genetic mutations in non-small-cell lung cancer (NSCLC) offers new therapeutic strategies. Identifying these driver alterations, like EGFR and ALK, improves treatment and patient survival.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Non-small-cell lung cancer (NSCLC), particularly adenocarcinoma, often relies on specific 'driver mutations' for tumor development.
  • These genetic alterations are crucial for inducing and sustaining tumorigenesis, making them key targets for treatment.

Framework:

  • Molecular classification of NSCLC is clinically relevant, with Epidermal Growth Factor Receptor (EGFR) mutations serving as a prime example.
  • This review focuses on known driving molecular alterations including ROS1, BRAF, KRAS, HER2, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and Anaplastic Lymphoma Kinase (ALK) rearrangements.

Implementation:

  • Targeting the protein products of driver mutations can lead to tumor growth inhibition and improved patient outcomes.
  • The article discusses the scope of these molecular alterations and their potential therapeutic applications.

Implications:

  • Identifying and targeting specific driver mutations in NSCLC allows for personalized treatment strategies.
  • This molecular-driven approach holds promise for enhancing treatment response and increasing patient survival rates in NSCLC.