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Published on: August 4, 2020
Personalized surgical therapy
1Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany. joerg.christian.tonn@med.uni-muenchen.de
Abstract:
Gliomas are more or less diffuse tumours with the ability to infiltrate surrounding functional brain tissue. Thus, curative surgical treatment generally cannot be achieved. Despite these limitations, open tumour resection represents one of the mainstays in glioma treatment settings. Beyond tissue sampling for accurate histological and molecular genetic evaluation, decompressive effects in the case of space occupying tumours and oncologically relevant cytoreductive effects of microsurgery have been reported in selected patients with glioma of different grades. This paper provides practical considerations in order to integrate the concept of a personalized surgical therapy into the prognostic network of low- and high-grade gliomas, covering both microsurgery and stereotactic biopsy techniques.
Insights
Personalized surgical therapy, including microsurgery and stereotactic biopsy, is key for managing gliomas. This approach aims to improve outcomes by considering individual patient factors and tumor characteristics for better glioma treatment.
Area of Science:
- Neuro-oncology
- Surgical Oncology
- Neurosurgery
Background:
- Gliomas are diffuse brain tumors infiltrating functional tissue, making curative surgery challenging.
- Despite infiltrative nature, tumor resection remains a cornerstone of glioma management.
- Surgical goals include histological/molecular evaluation, decompression, and cytoreduction.
Framework:
- Integrating personalized surgical therapy into glioma prognostic networks.
- Considering both low- and high-grade gliomas.
- Focus on tailoring treatment to individual patient and tumor characteristics.
Implementation:
- Microsurgery for debulking and cytoreduction.
- Stereotactic biopsy for accurate diagnosis and molecular profiling.
- Practical considerations for applying personalized approaches.
Implications:
- Enhanced prognostic accuracy for gliomas.
- Optimized surgical strategies for improved patient outcomes.
- Advancing the field of precision medicine in neuro-oncology.
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