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PAF antagonist ginkgolide B reduces postischemic neuronal damage in rat brain hippocampus
H Oberpichler1, D Sauer, C Rossberg
1Institut für Pharmakologie und Toxikologie, Marburg, F.R.G.
Abstract:
We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.