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A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
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Published on: August 11, 2012

Trichomoniasis and lactoferrin: future prospects.

Rakesh Sehgal1, Kapil Goyal, Alka Sehgal

  • 1Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. sehgalpgi@gmail.com

Infectious Diseases in Obstetrics and Gynecology
|September 19, 2012
PubMed
Summary
This summary is machine-generated.

Trichomonas vaginalis requires iron for survival and pathogenesis. This review examines how the parasite manages iron levels during fluctuating concentrations, identifying potential drug and vaccine targets.

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Area of Science:

  • Parasitology
  • Microbiology
  • Infectious Diseases

Background:

  • Trichomonas vaginalis is a protozoan parasite infecting the urogenital tract.
  • Iron is essential for T. vaginalis survival, influencing virulence factors like cytoadherence.
  • Lactoferrin in mucosal secretions chelates iron, creating a low-iron environment.

Purpose of the Study:

  • To review the role of iron in T. vaginalis survival amidst fluctuating iron concentrations.
  • To explore the parasite's mechanisms for iron acquisition at mucosal surfaces.
  • To identify potential therapeutic and prophylactic targets related to iron metabolism.

Main Methods:

  • Literature review focusing on iron acquisition and T. vaginalis pathogenesis.
  • Analysis of T. vaginalis's adaptation to varying iron levels, particularly during the menstrual cycle.
  • Identification of iron-related host-parasite interactions.

Main Results:

  • Iron upregulates adhesins and other virulence factors in T. vaginalis.
  • The parasite possesses mechanisms to overcome iron scarcity imposed by lactoferrin.
  • Fluctuating iron levels during the menstrual cycle impact T. vaginalis survival.

Conclusions:

  • Iron metabolism is critical for T. vaginalis pathogenesis and survival.
  • Understanding iron acquisition mechanisms offers opportunities for novel therapeutic strategies.
  • Targeting iron-dependent pathways could lead to new drugs and vaccines against trichomoniasis.