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Cow's Milk Allergy Is a Major Contributor in Recurrent Perianal Dermatitis of Infants

Mostafa Abdel-Aziz El-Hodhod1, Ahmad Mohamed Hamdy, Marwa Talaat El-Deeb

  • 1Department of Pediatrics, Faculty of Medicine, Ain Shams University, Abbassia, Cairo 11566, Egypt.

ISRN Pediatrics
|September 19, 2012
PubMed

Insights

Cow's milk allergy (CMA) is a common cause of recurrent perianal dermatitis in infants. Symptoms like bloody stool and vomiting can indicate CMA.

Area of Science:

  • Pediatrics
  • Allergy and Immunology
  • Dermatology

Background:

  • Recurrent perianal inflammation in infants presents diverse etiological factors.
  • Cow's milk allergy (CMA) is a potential, yet often overlooked, cause of persistent perianal dermatitis.
  • Assessing the prevalence and predictive factors of CMA in this context is crucial for effective management.

Purpose of the Study:

  • To determine the etiological significance of cow's milk allergy (CMA) in infants presenting with recurrent perianal dermatitis.
  • To identify clinical predictors associated with CMA in this patient population.

Main Methods:

  • A follow-up clinical study involving 63 infants with chronic, recurrent perianal dermatitis.
  • Comprehensive diagnostic workup including clinical history, physical examination, stool analysis, cultures, and IgE testing for cow's milk.
  • Confirmation of CMA through an open withdrawal-rechallenge procedure.

Main Results:

  • Cow's milk allergy (CMA) was identified as the cause in 47.6% of infants with recurrent perianal dermatitis.
  • Other identified causes included bacterial dermatitis (17.46%), candidiasis (15.87%), enterobiasis (9.52%), and lactose intolerance (9.5%).
  • Predictive factors for CMA included bloody/mucoid stool, other atopic manifestations, anal fissures, and recurrent vomiting.

Conclusions:

  • Cow's milk allergy (CMA) is a significant and common cause of recurrent perianal dermatitis in infants.
  • Clinical signs such as mucoid/bloody stool, anal fissures, vomiting, and atopic symptoms are valuable predictors of CMA.
  • Early identification and diagnosis of CMA can lead to improved treatment outcomes for affected infants.

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