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Related Concept Videos

Amyloid Fibrils03:03

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Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
11:04

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Published on: June 23, 2018

Evolutionary selection for protein aggregation.

Natalia Sanchez de Groot1, Marc Torrent, Anna Villar-Piqué

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K. nsdgroot@mrclmb.cam.ac.uk

Biochemical Society Transactions
|September 20, 2012
PubMed
Summary
This summary is machine-generated.

Protein aggregation, linked to diseases, offers evolutionary advantages. Cells evolved mechanisms to control potentially harmful aggregation-prone sequences, balancing risks and benefits.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Protein aggregation is implicated in numerous human diseases, causing either loss of protein function or toxic gain of function.
  • Despite potential harm, aggregation-prone sequences are widespread across life, suggesting inherent biological advantages.
  • These segments play crucial roles in protein folding and mediating protein-protein interactions, and cells utilize aggregates functionally.

Purpose of the Study:

  • To review the evolutionary advantages of aggregation-prone sequences in proteomes.
  • To summarize cellular strategies for controlling protein aggregation.

Main Methods:

  • Literature review of existing research on protein aggregation.
  • Analysis of the dual role of aggregation-prone sequences in biological systems.
  • Synthesis of information on cellular mechanisms for managing protein aggregation.

Main Results:

  • Aggregation-prone sequences, while linked to disease, are essential for fundamental biological processes.
  • Cells have developed sophisticated systems to tolerate and regulate these sequences, preventing detrimental aggregation.
  • The ubiquity of these sequences points to a conserved evolutionary strategy balancing risk and utility.

Conclusions:

  • Protein aggregation is a double-edged sword, essential for life but also a source of disease.
  • Understanding cellular control mechanisms for aggregation is key to addressing protein misfolding diseases.
  • Life's adaptation to aggregation-prone sequences highlights a fundamental principle of biological regulation.