Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study.

Journal of neurology·2023
Same author

Atrial fibrillation in cryptogenic stroke and TIA patients in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Main results.

European stroke journal·2023
Same author

Underlying causes of cryptogenic stroke and TIA in the nordic atrial fibrillation and stroke (NOR-FIB) study - the importance of comprehensive clinical evaluation.

BMC neurology·2023
Same author

Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke.

Journal of internal medicine·2020
Same author

Contrasting associations between breeding coloration and parasitism of male Arctic charr relate to parasite species and life cycle stage.

Scientific reports·2019
Same author

Visual field defect after ischemic stroke-impact on mortality.

Acta neurologica Scandinavica·2017

Related Experiment Video

Updated: May 18, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

TPA for ischemic stroke in patients ≥80 years.

E H Henriksen1, U Ljøstad, A Tveiten

  • 1Department of Neurology, Sørlandet Hospital, Kristiansand, Norway. endre.henriksen@sshf.no

Acta Neurologica Scandinavica
|September 20, 2012
PubMed
Summary

Older patients (≥80 years) receiving thrombolysis for acute ischemic stroke face higher risks of symptomatic intracerebral hemorrhage and death. However, age does not impact their chances of a good functional outcome.

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Related Experiment Videos

Last Updated: May 18, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Area of Science:

  • Neurology
  • Geriatrics
  • Emergency Medicine

Background:

  • Randomized controlled trials (RCTs) for tissue plasminogen activator (tPA) in acute ischemic stroke (AIS) typically exclude patients over 80 years old.
  • Despite exclusion from trials, many centers administer tPA to elderly patients.
  • The impact of advanced age on tPA treatment outcomes in AIS remains an important clinical question.

Purpose of the Study:

  • To investigate whether age ≥80 years is an independent predictor of outcomes following tPA treatment for AIS.
  • To analyze the association between advanced age and specific adverse events (symptomatic intracerebral hemorrhage, death) and functional recovery.

Main Methods:

  • A retrospective study included 77 patients aged ≥80 years and 83 patients aged <80 years who received tPA within 4.5 hours of AIS onset.
  • Multiple logistic regression analyses were performed to assess the relationship between age (≥80 vs. <80 years) and outcomes.
  • Outcomes evaluated included symptomatic intracerebral hemorrhage (sICH), mortality at 3 months, and good functional outcome (modified Rankin Scale 0-1).

Main Results:

  • Age ≥80 years was significantly associated with an increased risk of sICH (OR, 18.2) and death (OR, 3.3) within 3 months.
  • Advanced age did not predict functional outcome at 3 months (mRS 0-1).
  • Other predictors of death included longer onset-to-treatment time (OTT), higher NIH Stroke Scale (NIHSS) score, and prior stroke. Shorter OTT and lower NIHSS predicted good functional outcome.

Conclusions:

  • Advanced age (≥80 years) may be an independent risk factor for sICH and mortality in the initial 3 months post-tPA for AIS.
  • Age does not appear to influence the likelihood of achieving a good functional outcome.
  • Treatment with tPA in patients over 80 years is suggested, with caution advised for those with longer onset-to-treatment times.