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Hypercalciuria and kidney function in children with haemophilia
S Ranta1, H Valta, H Viljakainen
1Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. susanna.ranta@ki.se
Haemophilia : the Official Journal of the World Federation of Hemophilia
|September 20, 2012
Summary
Children with haemophilia often experience intermittent hypercalciuria (high urinary calcium), potentially impacting bone and kidney health. Further research is needed to understand long-term renal effects in these patients.
Area of Science:
- Pediatric Nephrology
- Hematology
- Bone Metabolism
Background:
- Adults with hemophilia show increased chronic kidney disease incidence.
- Children with hemophilia exhibit higher urinary calcium and lower bone density despite prophylaxis.
- Persistent hypercalciuria can lead to nephrocalcinosis and impaired renal function.
Purpose of the Study:
- To assess the persistence of elevated urinary calcium excretion in children with hemophilia.
- To evaluate kidney function in children with hemophilia over a two-year period.
- To investigate potential links between hemophilia and renal health.
Main Methods:
- Retrospective analysis of urinary calcium excretion in 30 children with hemophilia over two years.
- Renal function assessment including blood and urine tests, blood pressure, and renal ultrasound.
- Monitoring of serum vitamin D concentrations and lifestyle factors.
Main Results:
- A significant number of children with hemophilia displayed intermittent hypercalciuria.
- Hypercalciuria was not correlated with age, hemophilia severity, or prior occurrences.
- Kidney function and renal ultrasounds were generally normal; one case showed a suspected kidney stone.
- Vitamin D levels improved following parental education and recommendations.
Conclusions:
- Hemophilia itself appears to predispose children to hypercalciuria.
- This hypercalciuria may negatively influence bone mineral content and kidney function.
- Long-term consequences, including adult hypertension and renal issues, require further investigation.
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