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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Genetic Lingo01:11

Genetic Lingo

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Related Experiment Video

Updated: May 18, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

[Hereditary optic neuropathies].

D Milea1, C Verny

  • 1Ophthalmologie, CHU d'Angers, 4, rue Larrey, 49000 Angers, France. damilea@chu-angers.fr

Revue Neurologique
|September 20, 2012
PubMed
Summary
This summary is machine-generated.

Hereditary optic neuropathies encompass diverse genetic conditions affecting the optic nerves. While differing in cause and presentation, they commonly result in optic nerve atrophy and vision loss, with emerging recognition of associated neurological signs.

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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
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Area of Science:

  • Ophthalmology and Genetics: Investigating hereditary optic neuropathies, a spectrum of genetic disorders impacting vision.

Context:

  • Hereditary optic neuropathies present with varied genetic transmissions including autosomal dominant, recessive, X-linked, and mitochondrial patterns.
  • Common conditions like Leber's hereditary optic neuropathy and autosomal dominant optic atrophy, despite distinct features, share optic nerve atrophy as a hallmark.

Purpose:

  • To review the heterogeneous nature of hereditary optic neuropathies.
  • To highlight the common endpoint of optic nerve atrophy and associated neurological findings in these conditions.

Summary:

  • These conditions affect both optic nerves, leading to a non-specific optic nerve atrophy.
  • Visual loss is the primary clinical feature, but other neurological signs are increasingly identified.

Impact:

  • Enhances understanding of the clinical spectrum and genetic basis of hereditary optic neuropathies.
  • Underscores the importance of recognizing associated neurological deficits beyond visual impairment for comprehensive patient management.