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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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Arterial aging: a brief review.

Oana Mirea1, I Donoiu, I E Pleşea

  • 1Department of Cardiology, University of Medicine and Pharmacy of Craiova, Romania. i.donoiu@gmail.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|September 20, 2012
PubMed
Summary
This summary is machine-generated.

Aging alters artery structure and function, increasing cardiovascular risk. Key changes include vessel enlargement, wall thickening, and reduced elasticity, with endothelial dysfunction playing a crucial role.

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Area of Science:

  • Cardiovascular science
  • Aging research
  • Vascular biology

Background:

  • Aging leads to detrimental changes in arterial structure and function, surpassing normal physiological adaptation.
  • These vascular changes elevate the risk of cardiovascular events in older individuals.
  • Consistent structural alterations include arterial dilatation, remodeling (wall thickening), and decreased elasticity.

Purpose of the Study:

  • To summarize the structural and functional changes in arteries associated with aging.
  • To highlight the role of endothelial dysfunction in age-related vascular alterations.
  • To mention ongoing research into novel therapies for age-related vascular changes.

Main Methods:

  • Review of existing literature on arterial aging.
  • Analysis of structural changes: luminal enlargement, wall thickening, and elasticity reduction.
  • Evaluation of functional changes, focusing on endothelial dysfunction.

Main Results:

  • Aging consistently causes arterial dilatation and remodeling.
  • A significant reduction in the elastic properties of arterial walls is observed with age.
  • Endothelial dysfunction is a key functional consequence of vascular aging.

Conclusions:

  • Aging-induced arterial changes significantly increase cardiovascular event risk.
  • Endothelial dysfunction is a critical factor in the functional decline of aging arteries.
  • Novel therapeutic strategies are being investigated to counteract or reverse these age-related vascular modifications.