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Stenotrophomonas maltophilia: to be or not to be a cystic fibrosis pathogen

Christine R Hansen1

  • 1Department of Paediatrics, CF Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. christine.hansen@rh.regionh.dk

Current Opinion in Pulmonary Medicine
|September 20, 2012
PubMed
Abstract

Insights

Stenotrophomonas maltophilia is identified in cystic fibrosis (CF) patients, but its role as a pathogen is debated. While it doesn't worsen outcomes, its presence may indicate more severe lung disease in CF patients.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Stenotrophomonas maltophilia (S. maltophilia) is a bacterium frequently found in cystic fibrosis (CF) patients.
  • Chronic S. maltophilia infection in CF is common, but its clinical significance remains controversial.

Purpose of the Study:

  • To review recent literature (last 1.5 years) on S. maltophilia in CF.
  • To determine if S. maltophilia should be classified as a 'true' pathogen in CF.

Main Methods:

  • Literature review of studies published within the last 1.5 years.
  • Analysis of microbiological characteristics, virulence factors, and resistance patterns.
  • Evaluation of clinical effects, including serological responses and impact on lung function.

Main Results:

  • S. maltophilia is identifiable, possesses virulence factors, facilitates cross-infection, and exhibits multidrug resistance.
  • CF patients with chronic S. maltophilia infection show reduced lung function and increased exacerbations.
  • No direct evidence of S. maltophilia causing a worse clinical outcome was found.

Conclusions:

  • S. maltophilia is a well-characterized bacterium with concerning microbiological properties.
  • Chronic S. maltophilia infection in CF patients is not directly linked to poorer clinical outcomes.
  • The presence of S. maltophilia may serve as an indicator of more advanced lung disease in CF.

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