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OATP1B1 polymorphism as a determinant of erythromycin disposition

C S Lancaster1, G H Bruun, C J Peer

  • 1Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Clinical Pharmacology and Therapeutics
|September 20, 2012
PubMed
Summary

Erythromycin metabolism is influenced by the OATP1B1 transporter, not just CYP3A4. Genetic variants in OATP1B1 (SLCO1B1) affect how the body processes this antibiotic, impacting its drug interactions.

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