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Published on: February 19, 2019

Baseline characteristics and mortality among people in care for chronic viral hepatitis: the chronic hepatitis cohort

Anne C Moorman1, Stuart C Gordon, Loralee B Rupp

  • 1Division of Viral Hepatitis National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. amoorman@cdc.gov

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 20, 2012
PubMed

Insights

Chronic viral hepatitis poses a significant health burden in the US. The Chronic Hepatitis Cohort Study (CHeCS) found higher hospitalization and mortality rates, especially in those born 1945-1964.

Area of Science:

  • Hepatology
  • Public Health
  • Epidemiology

Background:

  • The Chronic Hepatitis Cohort Study (CHeCS) is a prospective, longitudinal, observational study in the US.
  • It assesses the clinical impact of chronic viral hepatitis.
  • This report details cohort selection, demographics, and health outcomes.

Purpose of the Study:

  • To describe the baseline characteristics of patients with chronic viral hepatitis in the US.
  • To analyze demographic, insurance, biopsy, hospitalization, and mortality data.
  • To highlight the health burden of chronic viral hepatitis.

Main Methods:

  • Analysis of electronic health records from over 1.6 million adult patients (2006-2010).
  • Data collected from four integrated healthcare systems across the US.
  • Inclusion criteria focused on patients with chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) infections.

Main Results:

  • Chronic Hepatitis B Virus (HBV): 2202 patients, 50% aged 44-63, 57% male, 58% Asian/Pacific Islander. 5.1% Medicaid, 16.5% Medicare, 76.3% private insurance. 22.3% liver biopsy, 37.9% hospitalized.
  • Chronic Hepatitis C Virus (HCV): 8810 patients, 75% aged 44-63, 60% male, 23% black. 12% Medicaid, 23% Medicare, 62% private insurance. 38.4% liver biopsy, 44.3% hospitalized.
  • Mortality (2006-2010): 9% with HBV and 14% with HCV died, primarily those born 1945-1964.

Conclusions:

  • Chronic viral hepatitis represents a substantial health burden in the US.
  • Demographic, hospitalization, and mortality data underscore this impact.
  • Individuals born during 1945-1964 are particularly affected.
Abstract

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