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Monitoring Protein Adsorption with Solid-state Nanopores
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Published on: December 2, 2011

Single molecule sensing with solid-state nanopores: novel materials, methods, and applications.

Benjamin N Miles1, Aleksandar P Ivanov, Kerry A Wilson

  • 1Department of Chemistry, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.

Chemical Society Reviews
|September 20, 2012
PubMed
Summary

This review explores solid-state nanopore sensing, covering fabrication, surface modification, and advanced detection methods for novel sensor development.

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Area of Science:

  • Nanotechnology
  • Biosensing
  • Materials Science

Background:

  • Nanopores, both solid-state and biological, confine analytes to nanoscale volumes, driving innovation in sensing.
  • Solid-state nanopores offer advantages in fabrication and surface functionalization for tailored sensor applications.

Purpose of the Study:

  • To provide a tutorial review on solid-state nanopore sensing.
  • To highlight recent advancements in fabrication, modification, and detection strategies.
  • To benefit both new and experienced scientists in the field.

Main Methods:

  • Focus on recent developments in solid-state nanopore technology.
  • Discussion of fabrication methods derived from the semiconductor industry.
  • Exploration of chemical and bio-molecular surface modifications for targeted sensing.
  • Review of novel detection strategies beyond ionic-current blockade.

Main Results:

  • Solid-state nanopores enable sophisticated sensor development through advanced fabrication.
  • Surface functionalization allows for specific target detection and novel sensor functions.
  • Emerging detection techniques like optical, electronic, and force-based methods expand nanopore versatility.

Conclusions:

  • Solid-state nanopores are a versatile platform for advanced sensing applications.
  • Continued research into fabrication, modification, and detection will drive future innovations.
  • The field is rapidly evolving with new frontiers exciting the sensing community.