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Related Experiment Video

Updated: May 18, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

Metabolic checkpoints in activated T cells.

Ruoning Wang¹, Douglas R Green

¹Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. ruoning.wang@stjude.org

Nature Immunology

|September 20, 2012

Summary

This summary is machine-generated.

T lymphocytes rapidly proliferate during clonal selection, shifting metabolism to glycolysis and glutaminolysis. Specific metabolic checkpoints regulate T cell responses by sensing nutrient availability and influencing cell fate.

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Published on: October 19, 2021

Area of Science:

Immunology
Cell Biology
Metabolic Regulation

Background:

Clonal selection necessitates rapid lymphocyte proliferation, requiring significant energy and biosynthesis.
Activated T cells shift from fatty acid oxidation to glycolysis and glutaminolysis for metabolic support.

Purpose of the Study:

To define 'metabolic checkpoints' in T lymphocytes.
To illustrate how these checkpoints link metabolic status to cellular signaling and function.

Main Methods:

Analysis of metabolic pathways in activated T lymphocytes.
Investigation of signaling events influenced by metabolite availability.
Characterization of 'metabolic checkpoints' regulating T cell responses.

Main Results:

T cell activation involves a metabolic switch to glycolysis and glutaminolysis.
Metabolite availability and processing pathways interconnect with signaling pathways.
Defined 'metabolic checkpoints' sense metabolic status and modulate T cell proliferation, differentiation, and survival.

Conclusions:

Metabolic checkpoints are crucial regulators of T lymphocyte function during immune responses.
Understanding these checkpoints offers insights into controlling T cell fate and immunological outcomes.