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Related Experiment Video

Updated: May 12, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Malignant idiopathic anaphylaxis.

R Patterson¹, S Wong, M S Dykewicz

¹Department of Medicine, Northwestern University Medical School, Chicago, Ill 60611.

The Journal of Allergy and Clinical Immunology

|January 1, 1990

Summary

This summary is machine-generated.

This study introduces "malignant idiopathic anaphylaxis" (IA) for severe, corticosteroid-dependent cases. It highlights the need for new management strategies when standard treatments fail.

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Area of Science:

Allergy and Immunology
Clinical Medicine
Pharmacology

Background:

Idiopathic anaphylaxis (IA) presents diagnostic and management challenges.
Corticosteroid dependence is a recognized subset of IA.
Long-term management of severe IA often requires escalating treatment doses.

Observation:

A patient with generalized, frequent idiopathic anaphylaxis since 1985 required progressively higher prednisone doses.
The patient was classified as corticosteroid-dependent IA, unable to achieve remission or discontinue prednisone.
A trial of ketotifen showed no significant reduction in prednisone requirement.

Findings:

The patient's idiopathic anaphylaxis remained uncontrolled without substantial alternate-day prednisone (≥90 mg).
This case exemplifies a severe, potentially fatal form of IA.
The term "malignant IA" is proposed to categorize such refractory cases.

Implications:

"Malignant IA" may represent a distinct, severe phenotype requiring novel therapeutic approaches.
Current management strategies may be insufficient for corticosteroid-dependent IA.
Further research is needed to identify effective treatments for severe, refractory idiopathic anaphylaxis.