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Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers

G Francescato1, M Agosti, G Bedogni

  • 1Neonatology and NICU, Maternal and Child Department, Filippo Del Ponte Hospital, Varese, Italy.

Pediatric Obesity
|September 20, 2012
PubMed

Insights

Early retinol-binding protein (RBP) levels may predict infant growth changes. This study explored biochemical markers in infants born to mothers with gestational diabetes mellitus (GDM).

Area of Science:

  • Neonatal research
  • Pediatric endocrinology
  • Maternal-fetal medicine

Background:

  • Lack of established biochemical predictors for infant growth.
  • Gestational diabetes mellitus (GDM) impacts fetal development.
  • Need for early growth assessment tools.

Purpose of the Study:

  • Investigate associations between early biomarkers and infant growth.
  • Evaluate retinol-binding protein (RBP), docosahexaenoic acid, and insulin (I) as predictors.
  • Focus on infants born to mothers with GDM.

Main Methods:

  • Longitudinal study of 56 infants (GDM-I and GDM-D groups).
  • Biochemical markers measured within 72 hours of birth.
  • Growth assessed at 0, 1, 3, 6, and 12 months.

Main Results:

  • Early RBP levels and maternal BMI associated with weight changes.
  • Early RBP and insulin levels linked to length changes.
  • No significant differences observed between GDM-I and GDM-D infants.

Conclusions:

  • Early retinol-binding protein (RBP) levels show potential as a growth predictor.
  • Further research is warranted to validate RBP's predictive role.
  • Findings contribute to understanding GDM's impact on infant growth.
Abstract

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