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09:02
Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of Manganese(II) Acetylacetonate
Published on: June 18, 2020
Manganese: a new contrast agent for lung imaging?
Oliviero L Gobbo1, Magdalena Zurek, Frederic Tewes
1School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
Contrast Media & Molecular Imaging
|September 20, 2012
Summary
Manganese-enhancement MRI (MEMRI) shows promise for lung imaging. This study demonstrated MEMRI can significantly enhance signal intensity and image contrast in rat lung parenchyma.
Area of Science:
- Medical Imaging
- Pulmonary Medicine
- Biomedical Engineering
Background:
- Magnetic resonance imaging (MRI) faces challenges in imaging lung parenchyma due to tissue properties.
- Existing MRI techniques for lung imaging have limitations.
- Manganese-enhancement MRI (MEMRI) has not been extensively studied for pulmonary applications.
Purpose of the Study:
- To evaluate the efficacy of T(1)-enhancement using MEMRI in rat lung tissue.
- To assess the potential of MEMRI for improving signal intensity and contrast in lung imaging.
Main Methods:
- Utilized a 4.7 T magnet for MRI acquisition.
- Employed a radial ultrashort echo time sequence.
- Administered manganese chloride solution via instillation in rat lungs and compared with a control.
Main Results:
- Observed a significant increase in signal intensity in lungs treated with manganese compared to controls.
- Measured MR signal enhancements exceeding 30% in lung parenchyma.
- Demonstrated successful T(1)-enhancement in lung tissue using MEMRI.
Conclusions:
- MEMRI is a potentially valuable novel technique for pulmonary MRI.
- MEMRI can effectively enhance signal intensity and image contrast in lung tissue.
- Further research into MEMRI for lung imaging is warranted.
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