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Related Concept Videos

What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
Introduction to the Skeletal System01:20

Introduction to the Skeletal System

The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
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Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
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Adult and Embryonic Skeletal Muscle Microexplant Culture and Isolation of Skeletal Muscle Stem Cells
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A systems approach and skeletal myogenesis.

Yoshiaki Ito1, Tomohiro Kayama, Hiroshi Asahara

  • 1Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8510, Japan ; Department of Systems BioMedicine, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan.

Comparative and Functional Genomics
|September 20, 2012
PubMed
Summary

Understanding skeletal myogenesis requires analyzing gene regulation. A novel systems approach combined with WISH database, high-throughput screening, and microarray analysis revealed the critical gene network for muscle development.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Skeletal myogenesis involves intricate gene expression regulation.
  • Understanding genome-wide gene regulation is crucial for skeletal myogenesis research.
  • Systems biology approaches offer powerful tools for dissecting complex biological processes.

Purpose of the Study:

  • To introduce a novel systems approach for elucidating the myogenesis regulatory network.
  • To highlight the advantages of a systems approach in understanding gene regulation during muscle development.

Main Methods:

  • Utilized a systems approach integrating multiple high-throughput techniques.
  • Combined whole-mount in situ hybridization (WISH) database with screening and microarray analysis.
  • Developed a novel strategy for genome-wide gene regulation analysis.

Main Results:

  • Successfully identified a critical genome network regulating skeletal myogenesis.
  • Demonstrated the efficacy of the integrated systems approach in uncovering regulatory pathways.
  • Provided a comprehensive overview of the myogenesis regulatory network.

Conclusions:

  • The presented systems approach is effective for understanding complex gene regulatory networks.
  • This methodology provides valuable insights into skeletal myogenesis.
  • Further application of this approach can advance our understanding of muscle development and related disorders.