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Updated: May 18, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and
Jérôme Eeckhoute1, Frédérik Oger, Bart Staels
1Université Lille Nord de France, 59000 Lille, France ; Inserm, U1011, 59000 Lille, France ; UDSL, 59000 Lille, France ; Institut Pasteur de Lille, 59019 Lille, France.
Abstract:
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes. Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells. Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure. Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling. In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.
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