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Updated: May 18, 2026

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

Published on: January 30, 2026

Failed weaning from mechanical ventilation and cardiac dysfunction.

Jahan Porhomayon¹, Peter Papadakos, Nader D Nader

¹VA Western New York Healthcare System, Division of Critical Care Medicine, Department of Anesthesiology and Medicine, Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, NY 14215, USA.

Critical Care Research and Practice

|September 20, 2012

Summary

This summary is machine-generated.

Timely weaning from mechanical ventilation is crucial. Echocardiography and biomarkers may help predict successful spontaneous breathing trials (SBTs) in intensive care unit patients, especially those with cardiac issues.

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Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

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Published on: July 18, 2025

Area of Science:

Critical Care Medicine
Cardiology
Pulmonary Medicine

Background:

Delayed transition from mechanical ventilation to spontaneous breathing trials (SBTs) increases intensive care unit morbidity and mortality.
Weaning from mechanical ventilation is challenging in patients with compromised cardiac function.

Purpose of the Study:

To explore the utility of cardiac echocardiography and serum biomarkers in predicting successful weaning outcomes.
To assess hemodynamic responses during SBTs to guide clinical decisions.

Main Methods:

Utilizing recent advances in cardiac echocardiography.
Employing laboratory measurement of serum biomarkers.
Evaluating hemodynamic response to spontaneous breathing trials (SBTs).

Main Results:

Cardiac echocardiography may offer insights into patient tolerance of SBTs.
Serum biomarkers can provide objective measures of cardiac stress during weaning attempts.
These assessments may improve the prediction of successful weaning from mechanical ventilation.

Conclusions:

Integrating echocardiography and biomarker analysis into SBT protocols can enhance the prediction of weaning success.
This approach may help mitigate risks associated with prolonged mechanical ventilation and weaning failure.
Further research is warranted to validate these methods in diverse patient populations.