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Updated: May 18, 2026
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
Retinal function and morphology in central retinal vein occlusion with macular edema
Hidetaka Noma1, Tatsuya Mimura, Katsunori Shimada
1Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan. noma-hide@umin.ac.jp
Purpose/Aim:
To investigate the relations among best-corrected visual acuity (BCVA), macular sensitivity, macular thickness, and macular volume in patients with central retinal vein occlusion (CRVO) and macular edema.
Materials And Methods:
In 16 consecutive patients with CRVO (mean age: 71.9 ± 6.9 years; 10 women and six men), macular function was documented by microperimetry and BCVA was determined on the logarithm of the minimum angle of resolution scale. Macular thickness and macular volume were measured by optical coherence tomography (OCT), and mean macular sensitivity was calculated for each of nine macular subfields on the retinal map obtained by OCT.
Results:
BCVA was correlated with both macular thickness and macular volume in all nine subfields of the macular region. In contrast, macular sensitivity was correlated with both macular thickness and macular volume in six out of nine subfields (superior inner, superior outer, inferior inner, inferior outer, nasal inner, and nasal outer). The correlations were stronger in the nasal subfields than the other subfields.
Conclusions:
These findings suggest that evaluation of both visual acuity and macular sensitivity might be important when assessing visual function in CRVO patients with macular edema.
