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Creating Transient Cell Membrane Pores Using a Standard Inkjet Printer
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Comparative diffusivity measurements for alginate-based atomized and inkjet-bioprinted artificial cells using

Maryam Mobed-Miremadi1, Behrokh Asi, Jaino Parasseril

  • 1Department of Biomedical, Chemical and Materials Engineering, Davidson College of Engineering, San Jose State University, San Jose, CA 95192, USA. maryam.mobed-miremadi@sjsu.edu

Artificial Cells, Nanomedicine, and Biotechnology
|September 21, 2012
PubMed
Summary

Miniaturized alginate-based artificial cells exhibit enhanced diffusion. Inkjet-printed artificial cells showed significantly higher diffusivity for FITC-Dextran markers compared to larger, atomized capsules.

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Area of Science:

  • Biomaterials Engineering
  • Chemical Engineering
  • Drug Delivery Systems

Background:

  • Alginate-based artificial cells are promising for various applications.
  • Controlling diffusion across artificial cell membranes is crucial for their function.
  • Miniaturization may impact transport properties.

Purpose of the Study:

  • To investigate and compare the radial diffusivity profiles of atomized (MC) and inkjet-printed (MI) alginate-based artificial cells.
  • To quantify the passive outward diffusion of FITC-Dextrans across different sized capsules.
  • To determine the effect of miniaturization on diffusive properties.

Main Methods:

  • Generating atomized (MC) and inkjet-printed (MI) alginate-based artificial cells.
  • Utilizing 2D Fluorescence Microscopy to observe diffusion.
  • Measuring the outward diffusion of 4 kDa and 70 kDa FITC-Dextrans.
  • Quantifying diffusion using a Fickian model.

Main Results:

  • Inkjet-printed artificial cells (MI) demonstrated significantly higher outer layer diffusivities compared to atomized capsules (MC).
  • The ratio of outer layer diffusivities D(MIout)/D(MCout) was 4.25 for 4 kDa and 5.07 for 70 kDa FITC-Dextran markers.
  • These results indicate an enhanced diffusive potential in miniaturized capsules.

Conclusions:

  • Miniaturization via inkjet printing significantly enhances the diffusive capabilities of alginate-based artificial cells.
  • The enhanced diffusion in smaller capsules is attributed to their reduced size and potentially altered surface-to-volume ratio.
  • These findings have implications for designing artificial cells with tailored transport properties for applications like drug delivery.