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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Chronic kidney disease alters intestinal microbial flora
Nosratola D Vaziri1, Jakk Wong, Madeleine Pahl
1Division of Nephrology and Hypertension, UC Irvine Medical Center, Irvine, California 92868, USA. ndvaziri@uci.edu
Kidney International
|September 21, 2012
Summary
Uremia significantly alters the gut microbiome composition in patients with end-stage renal disease (ESRD) and in animal models. These changes in bacterial populations may impact kidney disease progression and require further investigation.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- The gut microbiome is a symbiotic ecosystem crucial for host health.
- The biochemical environment, including uremia in chronic kidney disease (CKD), can shape the microbiome.
- Understanding how CKD and uremia affect the gut microbiome is essential.
Purpose of the Study:
- To investigate the impact of uremia and CKD on the gut microbiome composition.
- To identify specific bacterial taxa altered in end-stage renal disease (ESRD) patients and uremic animal models.
Main Methods:
- Phylogenetic microarray analysis of microbial DNA from stool samples of ESRD patients and healthy controls.
- Comparative analysis of gut microbiome in rats 8 weeks post-5/6 nephrectomy (uremia model) versus sham operation.
Main Results:
- Significant differences in 190 bacterial operational taxonomic units (OTUs) between ESRD patients and controls.
- Marked increases in specific bacterial families (e.g., Enterobacteriaceae, Pseudomonadaceae) in ESRD patients.
- Significant alterations in 175 bacterial OTUs in uremic rats, with notable decreases in Lactobacillaceae and Prevotellaceae.
Conclusions:
- Uremia profoundly alters the gut microbiome composition.
- The biological implications of these uremia-induced microbiome changes are currently unknown and warrant further research.
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