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Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...

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Increased maternal microchimerism after open fetal surgery.

Payam Saadai1, Tippi C MacKenzie

  • 1Division of Pediatric Surgery and The Fetal Treatment Center, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

Chimerism
|September 21, 2012
PubMed
Summary
This summary is machine-generated.

Open fetal surgery increases maternal microchimerism, the presence of maternal cells in the fetus. This suggests surgical interventions may alter maternal-fetal cellular trafficking, impacting pregnancy outcomes.

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Area of Science:

  • Reproductive immunology
  • Developmental biology
  • Surgical innovation

Background:

  • Maternal-fetal cellular trafficking (MFCT) involves cell exchange between mother and fetus.
  • MFCT plays a role in maternal-fetal tolerance and can be altered in pregnancy complications.
  • The impact of surgical interventions on MFCT is not well understood.

Purpose of the Study:

  • To investigate whether open fetal surgery alters maternal and fetal microchimerism levels.
  • To compare microchimerism in fetuses undergoing open fetal surgery versus postnatal repair or healthy controls.

Main Methods:

  • Analysis of maternal and fetal microchimerism.
  • Comparison of microchimerism levels in three groups: fetuses undergoing open fetal surgery for spina bifida repair, fetuses undergoing postnatal repair, and healthy controls.

Main Results:

  • Maternal microchimerism levels were significantly increased in fetuses who underwent open fetal surgery compared to controls.
  • No increased microchimerism was observed in patients who had fetal intervention at the time of delivery.
  • Fetal microchimerism levels were not detailed in the provided abstract.

Conclusions:

  • Open fetal surgery may alter maternal-fetal cellular trafficking.
  • Findings suggest potential implications for understanding preterm labor and transplantation tolerance.
  • Further research is needed to elucidate the mechanisms and consequences of altered MFCT post-surgery.