Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview Of Cell Separation And Isolation01:20

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Membrane Merger Dynamics in Exocytosis and Endocytosis.

Advances in experimental medicine and biology·2026
Same author

A phosphoinositide switch from PI(4,5)P<sub>2</sub> to PI4P triggers endocytosis by inducing dynamin-mediated fission in secretory cells.

Science advances·2025
Same author

Nanoscopy Reveals Heparan Sulfate Clusters as Docking Sites for SARS-CoV-2 Attachment and Entry.

bioRxiv : the preprint server for biology·2025
Same author

Galectin-1 is associated with hematopoietic cell engraftment in murine MHC-mismatched allotransplantation.

Frontiers in immunology·2024
Same author

Neutrophil Heterogeneity Is Modified during Acute Lung Inflammation in Apoa1-/- Mice.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same author

Clathrin mediates membrane fission and budding by constricting membrane pores.

Cell discovery·2024
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

Standing surface acoustic wave (SSAW) based multichannel cell sorting.

Xiaoyun Ding1, Sz-Chin Steven Lin, Michael Ian Lapsley

  • 1Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.

Lab on a Chip
|September 21, 2012
PubMed
Summary
This summary is machine-generated.

We developed a new microfluidic device using acoustic waves for precise cell sorting. This label-free, non-invasive technology directs individual cells into five channels simultaneously.

More Related Videos

Fabrication of Surface Acoustic Wave Devices on Lithium Niobate
07:55

Fabrication of Surface Acoustic Wave Devices on Lithium Niobate

Published on: June 18, 2020

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids
05:17

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids

Published on: October 13, 2023

Related Experiment Videos

Last Updated: May 18, 2026

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations
06:51

Microparticle Manipulation by Standing Surface Acoustic Waves with Dual-frequency Excitations

Published on: August 21, 2018

Fabrication of Surface Acoustic Wave Devices on Lithium Niobate
07:55

Fabrication of Surface Acoustic Wave Devices on Lithium Niobate

Published on: June 18, 2020

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids
05:17

Three-Dimensional Acoustic Assembly Device for Mass Manufacturing of Cell Spheroids

Published on: October 13, 2023

Area of Science:

  • Biotechnology
  • Microfluidics
  • Acoustic Physics

Background:

  • Cell sorting is crucial for biological research and diagnostics.
  • Existing methods can be complex, invasive, or require cell labeling.

Purpose of the Study:

  • To develop a novel, label-free microfluidic cell sorting device.
  • To enable precise, high-throughput cell separation in continuous flow.

Main Methods:

  • Utilized tunable standing surface acoustic waves (SAW).
  • Engineered a microfluidic chip with five distinct outlet channels.
  • Implemented SAW to manipulate and direct individual cells.

Main Results:

  • Achieved precise, single-step sorting of individual cells.
  • Demonstrated a versatile, label-free, and non-invasive cell manipulation technique.
  • Showcased high controllability over cell trajectory within the microfluidic device.

Conclusions:

  • The novel microfluidic device offers an efficient and controllable method for cell sorting.
  • This technology has potential applications in various biological and medical fields.
  • The label-free and non-invasive nature makes it suitable for sensitive cell populations.