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Related Experiment Video

Updated: May 18, 2026

A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
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Published on: May 19, 2023

Pulmonary nodule size evaluation with chest tomosynthesis.

Åse A Johnsson1, Erika Fagman, Jenny Vikgren

  • 1Department of Radiology, the Sahlgrenska Academy at University of Gothenburg, and Department of Radiology, Sahlgrenska University Hospital, Bruna Straket 11, SE-413 45 Gothenburg, Sweden. ase.johns-son@gregion.se

Radiology
|September 21, 2012
PubMed
Summary

Chest tomosynthesis and computed tomography (CT) measurements of lung nodules show comparable results with similar repeatability. However, the limits of agreement suggest caution when interchanging measurements between chest tomosynthesis and CT.

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Area of Science:

  • Radiology
  • Medical Imaging
  • Thoracic Imaging

Background:

  • Accurate lung nodule size measurement is crucial for diagnosis and treatment planning.
  • Chest tomosynthesis offers a lower-radiation alternative to computed tomography (CT) for thoracic imaging.

Purpose of the Study:

  • To evaluate intra- and interobserver variability in nodule size measurements.
  • To assess agreement between chest tomosynthesis and CT for nodule size measurements.

Main Methods:

  • Eight observers measured nodule diameters on chest tomosynthesis and CT images.
  • Intra- and interobserver repeatability and agreement were assessed using Bland-Altman analysis.

Main Results:

  • Measurements on chest tomosynthesis and CT demonstrated comparable results with no significant bias.
  • Intraobserver limits of agreement for the longest diameter ranged from ±1.0 mm to ±1.8 mm for tomosynthesis and ±0.9 mm to ±2.2 mm for CT.
  • Interobserver limits of agreement for the longest diameter ranged from ±1.5 mm to ±2.1 mm for tomosynthesis and ±1.1 mm to ±3.1 mm for CT.

Conclusions:

  • Nodule size measurements are comparable between chest tomosynthesis and CT, with similar repeatability.
  • The observed limits of agreement indicate that measurements from the two modalities should not be used interchangeably.