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Updated: May 18, 2026
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Combining paclitaxel and lapatinib as second-line treatment for patients with metastatic transitional cell carcinoma:
Stéphane Culine1, Zineb Sellam, Linda Bouaita
1Department of Medical Oncology, Henri Mondor Hospital, Créteil, France. stephane.culine@sls.aphp.fr
Background:
Current first-line cisplatin-based combination chemotherapy regimens provide interesting response rates but limited impact on survival for patients with metastatic transitional cell carcinoma of the urothelium. Such results leave a significant patient population in need of salvage therapy.
Patients And Methods:
As the epidermal growth factor receptors 1 and 2 (EGFR and HER2) are frequently overexpressed in urothelial carcinoma, we explored the feasibility of a combination of paclitaxel (80 mg/m(2)/week) and lapatinib (1,500 mg orally daily) for six patients who were treated after failure of first-line platinum-based chemotherapy.
Results:
Only one out of six patients was able to receive the full doses during the first six weeks of treatment, while grade 2 or 3 diarrhea events required lapatinib dose reduction (one patient) or discontinuation (five patients), despite loperamide support.
Conclusion:
This combination is not recommended for this population of patients.
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