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High nuclear protein kinase CβII expression is a marker of disease recurrence in oral squamous cell carcinoma
Pei-Yi Chu1, Nicholas Chung-Heng Hsu, Shu-Hui Lin
1Department of Pathology, St Martin De Porres Hospital, Chiayi, Taiwan, ROC.
Background:
Protein kinase C beta II (PKCβII) is a member of the family of serine/threonine kinases which are involved in tumor formation and progression. This study investigated the significance of PKCβII in oral squamous cell carcinoma (OSCC).
Patients And Methods:
The expression of PKCβII was determined in tumors from 59 patients with OSCC using immunohistochemistry and was correlated with patients' clinical characteristics and outcomes.
Results:
Twenty-six cases (44%) exhibited nuclear PKCβII staining. High nuclear PKCβII expression was significantly associated with the consumption of betel quid (p=0.015) and alcohol (p=0.024) in OSCC. Kaplan-Meier analysis revealed a shorter time-to-recurrence in patients with high nuclear PKCβII expression (p=0.018). In multivariate analysis for recurrence, high nuclear staining of PKCβII remained an independent adverse prognostic factor (hazard ratio=2.3, p=0.016).
Conclusion:
The present study provides evidence of the potential prognostic value of PKCβII analysis in OSCC.
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