Related Experiment Video
Updated: May 18, 2026
12:27
Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
Published on: May 7, 2015
[Acid-base disturbances during liver transplantation]
Anesteziologiia I Reanimatologiia
|September 22, 2012
Summary
Metabolic acidosis during liver transplantation is primarily driven by lactate buildup before reperfusion and reduced cardiac output during the anhepatic phase. Acid-base balance is significantly impacted by lactate clearance and oxygen delivery.
Area of Science:
- Hepatology
- Transplant Surgery
- Anesthesiology
Context:
- Liver transplantation involves complex physiological challenges.
- Acid-base disturbances are common complications.
- Assessing these disturbances is crucial for patient outcomes.
Purpose:
- To evaluate the factors contributing to acid-base disturbances during liver transplantation.
- To analyze these factors across different stages of the procedure.
- To correlate physiological parameters with acid-base status.
Summary:
- Metabolic acidosis in the pre-anhepatic phase is linked to increased lactate due to impaired hepatic clearance and blood loss.
- During the anhepatic phase, reduced cardiac output and oxygen delivery significantly impact acid-base balance.
- Reperfusion triggers a surge in pH, lactate, and pCO2 due to the release of acidic substances and endogenous CO2.
Impact:
- Understanding these factors allows for targeted interventions to manage acid-base balance.
- Optimizing perioperative management can improve outcomes for liver transplant recipients.
- This research provides insights into the pathophysiology of acid-base derangements in major surgery.
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