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Published on: August 16, 2018
Sesquiterpene lactones from Inula helianthus-aquatica
Yaping Hua1, Jiangjiang Qin, Fei Zhang
1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Summary
This study identified eleven compounds, including seven sesquiterpene lactones, from the aerial parts of Inula helianthus-aquatica. These compounds were isolated and characterized for the first time from this plant species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Botany
Background:
- Inula helianthus-aquatica is a plant species with potential medicinal properties.
- Sesquiterpene lactones are a class of natural products known for diverse biological activities.
Purpose of the Study:
- To isolate and identify the chemical constituents, specifically sesquiterpene lactones, from the aerial parts of Inula helianthus-aquatica.
Main Methods:
- Aerial parts of Inula helianthus-aquatica were extracted and subjected to chromatographic techniques including silica gel, Sephadex LH-20, and preparative HPLC.
- Compounds were identified using physicochemical properties and spectroscopic data analysis.
Main Results:
- Seven sesquiterpene lactones and four other compounds were successfully isolated and identified.
- The identified compounds include 2-desoxy-4-epi-pulchellin, 6-acetoxy-4-hydroxy-1, 10H-pseudoguaia-11(13)-en-12,8-olide, 4-acetoxy-6-hydroxy-1, 10H-pseudoguaia-11(13)-en-12,8-olide, 8-epi-inuviscolide, 2,3,11,13-tetrahydroaromaticin, 11,13-dihydro-ergolide, 4-epipulchellin-2-O-acetate, 7-epiloliolide, loliolide, beta-sitosterol, and daucosterol.
Conclusions:
- This research marks the first report of the isolation and identification of these eleven compounds from Inula helianthus-aquatica.
- The findings contribute to the chemotaxonomic understanding of the Inula genus and provide a basis for further pharmacological investigations.
