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Updated: May 18, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Imaging-based selection in acute ischemic stroke trials - a quest for imaging sweet spots
Andrew M Demchuk1, Bijoy Menon, Mayank Goyal
1Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. ademchuk@ucalgary.ca
Annals of the New York Academy of Sciences
|September 22, 2012
Summary
Advanced imaging is crucial for selecting ischemic stroke patients for acute treatments. A new "3C" approach (core, clot, collaterals) offers a promising alternative for efficient clinical trial design.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Ischemic stroke is a complex disease, complicating acute treatment efficacy.
- Current advanced imaging techniques for patient selection have limitations.
Purpose of the Study:
- To propose an alternative imaging approach for patient selection in acute ischemic stroke.
- To optimize endovascular treatment trial design.
Main Methods:
- Utilizing CT for hemorrhage exclusion and diffusion-weighted MRI for ischemia demonstration.
- Introducing the "3C" approach: core lesion volume, clot assessment, and collateral circulation evaluation.
Main Results:
- The "3C" approach provides a comprehensive assessment of stroke characteristics.
- This method offers an "imaging sweet spot" for patient selection.
Conclusions:
- The "3C" approach is a valuable alternative to mismatch analysis for stroke imaging.
- This strategy can significantly improve the efficiency of endovascular treatment trials.
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