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Mineral and bone disorder in Chinese dialysis patients: a multicenter study

Xianglei Kong1, Luxia Zhang, Ling Zhang

  • 1Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, China.

BMC Nephrology
|September 22, 2012
PubMed

Insights

Mineral and bone disorder (MBD) in Chinese dialysis patients is suboptimal, with high rates of hyperphosphatemia. Treatment targets are not being met, indicating a need for improved MBD management in this population.

Area of Science:

  • Nephrology
  • Endocrinology
  • Public Health

Background:

  • Mineral and bone disorder (MBD) in chronic kidney disease (CKD) patients increases morbidity and mortality.
  • Limited data exists on MBD treatment status in developing countries, particularly among Chinese dialysis patients.

Purpose of the Study:

  • To assess the current status of MBD management in Chinese dialysis patients.
  • To identify factors associated with hyperphosphatemia in this population.

Main Methods:

  • A cross-sectional study involving 2074 haemodialysis (HD) and peritoneal dialysis (PD) patients from 28 hospitals.
  • Analysis of serum phosphorus (P), calcium (Ca), and intact parathyroid hormone (iPTH) levels.
  • Comparison of MBD target achievement with Dialysis Outcomes and Practice Study (DOPPS) 3 and 4 data.

Main Results:

  • Only 26.6%–39.6% of patients met Kidney Disease Outcomes Quality Initiative (K/DOQI) targets for P, Ca, and iPTH.
  • HD patients had higher serum P and Ca levels compared to PD patients.
  • Hyperphosphatemia was prevalent (57.4% in HD, 47.4% in PD) and associated with age, dialysis pattern, and region.

Conclusions:

  • MBD management is suboptimal in Chinese dialysis patients, with a significant hyperphosphatemia burden.
  • Urgent attention and improved strategies are needed to address MBD and hyperphosphatemia in this cohort.
Abstract

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