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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: May 18, 2026

Orthotopic Small Bowel Transplantation in Rats
09:16

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Published on: November 6, 2012

Organ donation: when should we consider intestinal donation.

Carl-Ludwig Fischer-Fröhlich1, Alfred Königsrainer, Randolph Schaffer

  • 1Region Baden-Württemberg, Deutsche Stiftung Organtransplantation, Stuttgart, Germany.

Transplant International : Official Journal of the European Society for Organ Transplantation
|September 22, 2012
PubMed
Summary

Establishing clear intestinal donor criteria is crucial for successful intestinal transplantation (IT). This study proposes specific guidelines to optimize donor selection and improve graft utilization in this vital procedure.

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Area of Science:

  • Transplantation immunology
  • Organ donation and procurement
  • Gastroenterology

Background:

  • Despite over 2300 intestinal transplantations (IT) globally, standardized donor criteria are lacking.
  • This absence creates confusion for healthcare professionals involved in organ donation and transplantation.
  • Existing literature lacks specific profiles for intestinal graft donors.

Purpose of the Study:

  • To review existing literature for intestinal donor criteria.
  • To propose a set of inclusion criteria for deceased intestinal graft donation.
  • To enhance the utilization of the limited intestinal donor pool.

Main Methods:

  • A Medline search was conducted in December 2011 for publications on human intestinal donor criteria.
  • Retrospective analysis of 39 deceased donors who provided intestinal grafts between January 2006 and December 2011.
  • Evaluation of donor characteristics and outcomes for isolated and multivisceral grafts.

Main Results:

  • No studies specifically detailed intestinal donor profiles among 3504 IT publications.
  • Donor age was the most frequently cited criterion, but inconsistently applied.
  • Suggested criteria include age 0-50 years, ICU stay <1 week, no blunt abdominal trauma, serum sodium <155 mmol/l, minimal transfusion needs, standard donor therapy, and size match.

Conclusions:

  • Standardized intestinal donor criteria are urgently needed to reduce confusion and improve efficiency.
  • The proposed criteria aim to optimize the selection of deceased donors for intestinal transplantation.
  • Implementing these guidelines can help maximize the use of available intestinal grafts.