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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Antimicrobial prescribing practice in UK equine veterinary practice.

L A Hughes¹, G Pinchbeck, R Callaby

¹Department of Epidemiology and Population Health Group, Institute of Infection and Global Health, School of Veterinary Science, University of Liverpool, Neston, UK.

Equine Veterinary Journal

|September 22, 2012

Summary

Antimicrobial prescribing in UK equine practice is often inappropriate, with incorrect doses and off-label use common. Implementing antimicrobial use guidelines could promote more prudent drug selection and administration in horses.

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Area of Science:

Veterinary Pharmacology
Equine Medicine
Antimicrobial Stewardship

Background:

Prudent antimicrobial use is crucial to combat bacterial resistance.
Antimicrobial resistance is a significant threat in both human and veterinary medicine.
Preserving the efficacy of antimicrobials requires careful administration.

Purpose of the Study:

To characterize antimicrobial prescribing patterns in UK equine veterinary practices.
To identify factors associated with antimicrobial prescribing decisions in horses.
To evaluate the prevalence of off-label and incorrect-dose antimicrobial use.

Main Methods:

A postal questionnaire survey was distributed to 740 UK veterinary surgeons treating horses.
The survey included clinical scenarios to assess prescribing habits.
Multivariable logistic regression analyzed factors influencing specific antimicrobial prescribing outcomes.

Main Results:

Only 38% of surveyed vets responded, with less than 1% of practices having antimicrobial use guidelines.
Trimethoprim-sulphonamides were the most frequent choice; 11% of prescriptions were off-label.
Incorrect dosing was prevalent, with 56% of licensed antimicrobial prescriptions exceeding recommended rates.

Conclusions:

Inappropriate antimicrobial dosing in horses is common, even with patient weight data.
UK equine practices rarely have formal antimicrobial use guidelines.
Developing and implementing such guidelines could significantly improve antimicrobial stewardship in equine practice.