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White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
Published on: September 9, 2025
Plasma adiponectin before and after kidney transplantation
Thomas Idorn1, Mads Hornum, Mette Bjerre
1Department of Nephrology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. thomas.idorn@rh.regionh.dk
Summary
Plasma adiponectin (ADPN) levels decrease significantly after kidney transplantation (Tx). Pretransplant ADPN did not predict new-onset diabetes or glucose intolerance post-Tx, despite associations with kidney function and BMI.
Area of Science:
- Nephrology
- Endocrinology
- Immunology
Background:
- The role of plasma adiponectin (ADPN) in kidney disease and post-kidney transplantation (Tx) is unclear.
- Understanding factors influencing ADPN levels is crucial for managing metabolic complications.
Purpose of the Study:
- To investigate if pretransplant ADPN predicts glucose tolerance deterioration, including new-onset diabetes mellitus after Tx.
- To identify parameters affecting ADPN concentration before and after kidney Tx.
Main Methods:
- Studied 57 non-diabetic kidney recipients and 40 non-diabetic uraemic patients.
- Assessed ADPN levels, estimated glomerular filtration rate (eGFR), BMI, and insulin sensitivity.
- Analyzed data using multivariate and ordinal logistic regression.
Main Results:
- ADPN levels significantly decreased post-Tx, while eGFR increased.
- eGFR, BMI, and insulin sensitivity index were independently associated with ADPN.
- Pretransplant ADPN did not predict glucose tolerance aggravation post-Tx.
Conclusions:
- Kidney transplantation leads to a significant reduction in ADPN concentration.
- Kidney function, insulin resistance, BMI, and immunosuppressive agents influence ADPN levels.
- Pretransplant ADPN is not a predictor for new-onset diabetes or glucose intolerance following Tx.
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