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Probable levetiracetam-related serum alkaline phosphatase elevation
Nian Xiong1, Lingling Hou, Na Lu
1Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022 , Hubei, China.
BMC Neurology
|September 22, 2012
Summary
Levetiracetam (LEV) use in children may cause elevated alkaline phosphatase (ALP) levels. Discontinuing LEV normalized ALP, suggesting a probable drug-induced effect requiring cautious monitoring in pediatric epilepsy patients.
Area of Science:
- Pediatric Neurology
- Pharmacovigilance
- Clinical Biochemistry
Background:
- Levetiracetam (LEV) is a widely used antiepileptic drug.
- It is generally known for its favorable safety and tolerability profile.
- LEV is considered to have minimal impact on liver function.
Observation:
- A case of a pediatric patient on LEV monotherapy is presented.
- The patient exhibited a significant increase in serum alkaline phosphatase (ALP) levels.
- Serum ALP levels returned to normal upon discontinuation of LEV.
Findings:
- The Naranjo scale indicated a probable association between LEV and elevated ALP.
- This case highlights a potential, previously under-recognized adverse effect of LEV.
- The observed elevation in ALP was reversible after drug withdrawal.
Implications:
- Clinicians should be aware of the potential for LEV to cause elevated ALP, particularly in pediatric populations.
- Monitoring of ALP levels may be warranted in children treated with LEV.
- This finding necessitates cautious consideration of LEV use and potential side effects in epilepsy management.
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