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Double-walled hollow polymeric microspheres with independent pH and temperature dual-responsive and
Pengcheng Du1, Tingmei Wang, Peng Liu
1State Key Laboratory of Applied Organic Chemistry and Institute of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
The magnetic-targeting stimuli-responsive hollow polymeric microspheres show unique performance as the intelligent carriers for the site specific controlled delivery of drugs or genes. In the work, the well-defied dual-responsive double-walled hollow microspheres with movable magnetic cores were prepared from the penta-layer onion-shaped core-shell microspheres. Their double-walled shells were independent, with the pH-responsive crosslinked poly(methacrylic acid) (PMAA) layer as the inner shell and the temperature responsive crosslinked poly(N-isopropylacrylamide) (PNIPAM) layer as the outer shell. The combination of the pH and temperature dual-responsive and the magnetic-targeting function make the hollow microspheres to be the most promising intelligent carriers in the biomedical fields.
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