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Heart Valves

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
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Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

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Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Single Pipe Systems

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Aortic Regurgitation III: Medical Management

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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

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Related Experiment Video

Updated: May 18, 2026

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

Edwards CENTERA valve.

Henrique Barbosa Ribeiro¹, Marina Urena, Karl-Heinz Kuck

¹Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

|September 22, 2012

Summary

This summary is machine-generated.

The new Edwards CENTERA transcatheter aortic valve implantation (TAVI) device shows promise for treating severe aortic stenosis. Its design allows for precise placement and repositioning, potentially reducing TAVI complications.

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Area of Science:

Cardiology
Medical Devices
Interventional Cardiology

Background:

Transcatheter aortic valve implantation (TAVI) is a key treatment for high-risk severe symptomatic aortic stenosis.
Despite advancements, TAVI procedures can still lead to complications.
Improvements in transcatheter heart valve (THV) technology are needed for better device function, deliverability, and repositioning.

Purpose of the Study:

To describe the novel self-expandable Edwards CENTERA THV.
To evaluate the potential benefits of its motorized, low-profile delivery system for accurate valve placement and repositioning.
To present initial clinical experience with the CENTERA THV system.

Main Methods:

Description of the Edwards CENTERA THV, featuring nitinol construction and treated bovine pericardial tissue.
Utilisation of a motorized, low-profile delivery system designed for single-operator use.
Presentation of first-in-human clinical data.

Main Results:

The CENTERA THV is a self-expandable device with a nitinol frame and pericardial leaflets.
The delivery system facilitates accurate valve deployment and allows for repositioning.
Initial first-in-human clinical experience with the CENTERA THV has yielded promising outcomes.

Conclusions:

The Edwards CENTERA THV represents an advancement in TAVI technology.
The device's design may enhance procedural accuracy and reduce complications.
Larger studies with extended follow-up are necessary to validate these preliminary findings.