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Related Experiment Video

Updated: May 18, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

Citalopram and cardiac toxicity.

M J Cooke¹, W S Waring

¹Pharmacy Department, York Teaching Hospital NHS Foundation Trust, Wigginton Road, York, YO31 8HE, UK.

European Journal of Clinical Pharmacology

|September 22, 2012

Summary

High doses of citalopram, a selective serotonin reuptake inhibitor (SSRI) antidepressant, can cause QT prolongation and cardiac issues. Caution is advised with high doses or in patients with risk factors for cardiac effects.

Area of Science:

Cardiology
Pharmacology
Psychiatry

Background:

Citalopram is a widely prescribed SSRI antidepressant.
Recent findings suggest high therapeutic doses may induce electrocardiographic abnormalities.
Regulatory bodies have updated citalopram dosage recommendations.

Purpose of the Study:

To review existing data on citalopram and cardiac toxicity.
To examine cardiac effects associated with both therapeutic use and overdose.

Main Methods:

Systematic review of published literature on citalopram's cardiac effects.
Analysis of clinical data distinguishing between therapeutic use and overdose scenarios.

Main Results:

Electrocardiographic abnormalities, including QT prolongation and torsades de pointes, are known complications of citalopram overdose.

Related Experiment Videos

Last Updated: May 18, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

QT prolongation and arrhythmia are less common but increasingly recognized with therapeutic doses, with a recently established dose-effect relationship.

Patients with metabolic disturbances or pre-existing cardiac conditions are more susceptible to citalopram-induced QT prolongation.

Conclusions:

A dose-dependent relationship exists for citalopram-induced QT prolongation across various doses.
Prescribers should exercise caution with high citalopram doses, especially in patients with co-existing cardiac risk factors.
Clinical toxicity data may provide earlier warnings of cardiac effects compared to traditional pharmacovigilance.