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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

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Published on: August 30, 2019

From mice to humans.

Fiona McMurray¹, Lee Moir, Roger D Cox

¹MRC Harwell, Mammalian Genetics Unit, Medical Research Council, Harwell Science and Innovation Campus, Oxfordshire, OX11 0RD, UK.

Current Diabetes Reports

|September 22, 2012

Summary

This summary is machine-generated.

Mouse models are crucial for understanding diabetes and obesity genetics. Researchers are using advanced resources like gene knockouts and the International Mouse Phenotyping Consortium to identify gene functions and create new models for human mutations.

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

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Last Updated: Jan 19, 2026

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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Area of Science:

Genetics
Genomics
Metabolic Diseases

Background:

Genome sequencing projects have provided comprehensive genetic data for humans and mice.
Significant advancements have been made in understanding the genetic basis of diabetes and obesity.
Functional characterization of mapped genetic loci remains a key challenge in human population studies.

Purpose of the Study:

To highlight the indispensable role of mouse models in functional gene identification and characterization.
To review available mouse resources for genetic research.
To discuss the application of novel technologies in creating disease-specific mouse models.

Main Methods:

Utilizing comprehensive mouse genetic resources, including conditional knockout libraries for every gene.
Leveraging the International Mouse Phenotyping Consortium's efforts to link genes with phenotypic data.
Exploring the potential of TALEN (Targetedשלם DNA Endonuclease) technology for precise genetic engineering.
Analyzing engineered mouse models for specific human disease-associated genes (e.g., FTO, TCF7L2, CDKAL1, SLC30A8).

Main Results:

Availability of extensive mouse genetic resources facilitates functional genomics.
The International Mouse Phenotyping Consortium is systematically assigning phenotypes to mouse genes.
Engineered mouse models are instrumental in validating the function of genes implicated in GWAS for diabetes and obesity.
TALEN technology offers a powerful tool for creating bespoke mouse models of human genetic mutations.

Conclusions:

Mouse models are essential tools for dissecting the complex genetic architecture of diabetes and obesity.
Integrated approaches using genetic resources, phenotyping consortia, and advanced engineering technologies accelerate gene function discovery.
Further research in engineered mouse models will enhance our understanding of disease mechanisms and inform therapeutic strategies.