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Calcium dobesilate may improve hemorheology in patients undergoing coronary artery bypass grafting

Kazim Besirli1, Birsen Aydemir, Caner Arslan

  • 1Cardiovascular Surgery Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. birsenay2001@yahoo.com

Revista Brasileira De Cirurgia Cardiovascular : Orgao Oficial Da Sociedade Brasileira De Cirurgia Cardiovascular
|September 22, 2012
PubMed

Insights

Calcium dobesilate improved erythrocyte flexibility in patients after myocardial revascularization. However, it did not significantly alter blood viscosity, oxidative stress markers, or clinical outcomes like CCS class.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hemodynamics

Background:

  • Calcium dobesilate is an angioprotective agent with antioxidant properties.
  • It enhances endothelial-derived vasodilator secretion.
  • Its effects in the postoperative period following myocardial revascularization remain under-investigated.

Purpose of the Study:

  • To evaluate the impact of calcium dobesilate on hemorheological parameters.
  • To assess changes in oxidant and antioxidant markers (reduced glutathione and malondialdehyde).
  • To determine effects in patients undergoing myocardial revascularization post-surgery.

Main Methods:

  • A study involving 134 patients undergoing coronary heart disease surgery.
  • Measurement of hemorheological, oxidant, and antioxidant parameters pre- and post-treatment.
  • A treatment group received 500 mg calcium dobesilate twice daily for three months; a control group did not.

Main Results:

  • Significant improvement in erythrocyte deformability index observed post-calcium dobesilate administration.
  • No significant changes noted in blood viscosity, glutathione (GSH), or malondialdehyde (MDA) levels.
  • Similar improvement in Canadian Cardiovascular Society (CCS) class observed in both treatment and control groups.

Conclusions:

  • Calcium dobesilate significantly enhances erythrocyte flexibility.
  • The drug did not demonstrate significant effects on blood viscosity or key oxidative stress markers.
  • Clinical improvement in CCS class was independent of calcium dobesilate treatment in this cohort.
Abstract

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