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Pre-concentration of non-steroidal anti-inflammatory drugs in water using dispersive liquid-liquid and single-drop
Ali Sarafraz-yazdi1, Hakimeh Assadi, Zarrin Es'haghi
1Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Iran. asyazdi@um.ac.ir
Abstract:
In the present work the combination of two liquid-phase microextraction techniques involving dispersive liquid-liquid microextraction and single-drop microextraction as a new pre-concentration technique is developed for the separation and determination of acidic non-steroidal anti-inflammatory pharmaceutical compounds, namely, naproxen, diclofenac, and ibuprofen, in water samples using high-performance liquid chromatography ultra violet-detection. The extraction conditions were optimized and, under the optimal conditions, the method showed good linearity range of 0.1-1000 μg L(-1) (R > 0.9990), acceptable reproducibilities (relative standard deviation% = 4.5-8.8%), low limits of detection (0.03-0.2 μg L(-1) ), and satisfactory relative recoveries. The developed method was applied for the determination of anti-inflammatory drugs in river and waste water samples.
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