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Related Concept Videos

Colloids and Suspensions01:17

Colloids and Suspensions

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...

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Updated: May 18, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

Colloids in the intensive care unit.

Rachel M Kruer1, Christopher R Ensor

  • 1Surgical Intensive Care, The Johns Hopkins Hospital, Baltimore, MD 21287-6180, USA. rkruer1@jhmi.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|September 22, 2012
PubMed
Summary
This summary is machine-generated.

In critical care, colloids like albumin offer benefits but carry risks. Crystalloids are safer for trauma patients, while colloids may aid cardiac surgery and burn patients.

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Area of Science:

  • Critical care medicine
  • Fluid resuscitation pharmacology
  • Clinical trial analysis

Background:

  • Colloids and crystalloids are primary fluid resuscitation agents.
  • Evidence on their comparative safety and efficacy is evolving.
  • Population-specific responses necessitate nuanced clinical decision-making.

Purpose of the Study:

  • To review current evidence on colloid versus crystalloid use in critical care.
  • To analyze safety and efficacy differences across patient populations.
  • To inform fluid resuscitation strategies based on recent findings.

Main Methods:

  • Systematic review of published literature.
  • Analysis of key clinical trials, including the Saline Versus Albumin Fluid Evaluation (SAFE) trial.
  • Meta-analysis of relevant studies on sepsis and critical care populations.

Main Results:

  • Colloids have theoretical advantages but potential adverse effects (e.g., hydroxyethyl starch, dextrans).
  • Increased mortality risk observed with colloids in trauma and traumatic brain injury patients.
  • Comparable outcomes between crystalloids and albumin in severe sepsis.
  • Albumin use supported for extracorporeal cardiopulmonary bypass and select burn injuries.

Conclusions:

  • Avoid colloids in trauma and traumatic brain injury patients due to increased mortality.
  • Crystalloids and albumin show similar outcomes in severe sepsis.
  • Albumin may offer survival benefits in cardiac surgery and is a first-line alternative.
  • Supplemental colloids may be considered for specific burn patient populations.