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Related Experiment Video

Updated: May 18, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Is There a Place for Screening Flexible Sigmoidoscopy?

Doron Boltin¹, Yaron Niv

¹Department of Gastroenterology, Rabin Medical Center, Tel Aviv University, 39 Jabotinski Street, Petach Tikva 49100, Israel.

Current Colorectal Cancer Reports

|September 22, 2012

Summary

Flexible sigmoidoscopy shows promise for colorectal cancer (CRC) screening, with one trial reporting significant reductions in CRC incidence and mortality. However, results vary, and the procedure has limitations in detecting all cancers.

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Last Updated: May 18, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Area of Science:

Gastroenterology
Oncology
Preventive Medicine

Background:

Colorectal cancer (CRC) remains a significant health concern, necessitating effective early detection strategies.
Flexible sigmoidoscopy is a widely considered screening modality for CRC.
Conflicting evidence exists regarding the long-term efficacy of flexible sigmoidoscopy in reducing CRC incidence and mortality.

Purpose of the Study:

To evaluate the effectiveness of flexible sigmoidoscopy as a screening tool for early colorectal cancer detection.
To analyze long-term data from randomized controlled trials investigating flexible sigmoidoscopy's impact on CRC outcomes.

Main Methods:

Review of long-term data from the UK Flexible Sigmoidoscopy Screening Trial (UKFSST), a randomized controlled trial.
Comparison of UKFSST results with data from the Norwegian Colorectal Cancer Prevention (NORCCAP) trial.

Main Results:

The UKFSST demonstrated a 33% reduction in CRC incidence and a 43% decrease in CRC mortality with once-in-a-lifetime screening.
The NORCCAP trial, using a similar protocol, showed no significant reduction in CRC incidence or mortality at 7 years.
Flexible sigmoidoscopy has limitations, detecting only up to 70% of cancers and missing proximal neoplasms not associated with distal lesions.

Conclusions:

Flexible sigmoidoscopy is a potentially valuable tool for colorectal cancer screening, offering significant reductions in incidence and mortality in some studies.
The efficacy of flexible sigmoidoscopy may vary, highlighting the need for further research and consideration of its limitations.
Its safety, patient acceptance, technical simplicity, and cost-effectiveness support its use in mass screening programs.