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[Study on intestinal absorption of mollugin and purpurin in rats]
Kan Wang1, Xing Chen, Mingqiu Shan
1Nanjing University of Chinese Medicine, Nanjing 210046, China. wangkan86@hotmail.com
Objective:
To study the absorption kinetic characteristics of mollugin and purpurin in each intestinal segment of rats.
Method:
The in situ single-way perfusion rat model was established to study absorption characteristics of mollugin and purpurin in each intestinal segment of rats. The volume of recirculation fluid was regulated by phenol red.
Result:
Different quality concentrations (12.33, 24.66, 49.32 mg x L(-1)) of mollugin and (8.455, 16.91, 33.82 mg x L(-1)) purpurin showed a concentration gradient of absorption dose in each intestinal segment, with the osmotic coefficient increasing to more than 0.2 x 10(-4) cm x s(-1). In the same concentration, mollugin and purpurin showed an identical trend of P(eff) in each intestinal segment in the order of colon > duodenum > ileum > jejunum, with a significant difference (P < 0.05).
Conclusion:
Mollugin and purpurin are highly permeable in rat intestinal segments, with absorption in each segment, while the specific absorption existed in the colon segment.
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