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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
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Induced pluripotent stem cells for peripheral nerve regeneration.

Wen Xu1, Charles S Cox, Yong Li

  • 1The Department of Neuroscience, University of Pittsburgh, PA 15213, USA.

Journal of Stem Cells
|September 25, 2012
PubMed
Summary

Induced pluripotent stem (iPS) cells offer potential for treating neurological damage. This review explores their use in cell replacement therapy for peripheral nerve injuries, addressing the scarcity of neural stem cells.

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Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Stem Cell Biology

Background:

  • Induced pluripotent stem (iPS) cells, discovered in 2006, hold significant therapeutic promise.
  • The nervous system has limited regenerative capacity, making damage often permanent.
  • Neurology stands to benefit greatly from therapeutic applications of iPS cells.

Purpose of the Study:

  • To review the potential of induced pluripotent stem (iPS) cells in neurological treatments.
  • To discuss the application of iPS cells for peripheral nerve injury repair.

Main Methods:

  • Review of existing literature on iPS cell generation and differentiation.
  • Exploration of iPS cell potential in nervous system repair.

Main Results:

  • iPS cells can be differentiated into various cell types, including neural cells.
  • Cell replacement therapy using iPS cells is a viable strategy for nervous system damage.

Conclusions:

  • Induced pluripotent stem (iPS) cells represent a promising avenue for treating peripheral nerve injuries.
  • Further research into iPS cell differentiation and transplantation is warranted for neurological applications.