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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

[Endothelial dysfunction and apoptosis at early stage of chronic kidney disease]

A V Smirnov, N N Petrishchev, M M Mnuskina

    Terapevticheskii Arkhiv
    |September 25, 2012
    PubMed

    Insights

    Endothelial dysfunction and elevated endothelin-1 and annexin A5 levels are common in early chronic kidney disease (CKD). These factors independently impact endothelium-dependent vasodilation in CKD stages I-II.

    Area of Science:

    • Nephrology
    • Cardiovascular Research
    • Cell Biology

    Context:

    • Chronic kidney disease (CKD) affects endothelial function.
    • Early stages of CKD (I-IIIb) exhibit significant changes.
    • Endothelial dysfunction is a key factor in cardiovascular complications of CKD.

    Purpose:

    • To investigate changes in apoptosis and endothelial function in patients with CKD stages I-IIIb.
    • To identify biomarkers associated with endothelial dysfunction in early CKD.
    • To determine the impact of endothelin-1 and annexin A5 on endothelium-dependent vasodilation.

    Summary:

    • Reduced endothelium-dependent vasodilation (EDV) was observed in 34-70% of CKD patients across stages I-IIIb.
    • Elevated endothelin-1 (ET-1) levels were found in 41-83% of CKD patients.
    • Annexin A5 concentration significantly increased even in stage I CKD, correlating negatively with GFR.

    Impact:

    • Endothelin-1 and annexin A5 levels independently influence EDV in early CKD (stages I-II).
    • Findings highlight potential therapeutic targets for preserving endothelial function in CKD.
    • Early detection and management of endothelial dysfunction markers are crucial in CKD progression.
    Abstract

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