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Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Inflammation, adiposity, and mortality in the oldest old.
Inna Lisko1, Kristina Tiainen, Sari Stenholm
1Gerontology Research Center, School of Health Sciences, University of Tampere, Finland. inna.lisko@uta.fi
Rejuvenation Research
|September 25, 2012
Summary
In the oldest old, adiposity and inflammation interact differently with mortality in men and women. Low waist circumference and inflammation protected women, while high BMI and waist circumference protected men.
Area of Science:
- Gerontology
- Immunology
- Epidemiology
Background:
- Pro-inflammatory status is linked to increased adiposity and mortality risk.
- Mild obesity paradoxically does not predict increased mortality in older adults.
- Investigating inflammatory markers, adiposity, and mortality in nonagenarians is crucial.
Purpose of the Study:
- To examine associations between inflammatory markers and body composition (BMI, WC, WHR) in nonagenarians.
- To determine the combined effects of body composition and inflammatory status on mortality in this age group.
Main Methods:
- Prospective population-based study (Vitality 90+) in Finland.
- 157 women and 53 men aged 90 years underwent anthropometric measurements and blood sampling.
- Four-year mortality follow-up, with inflammatory status assessed via IL-1RA, IL-6, CRP, and TNF-α levels.
Main Results:
- In women, IL-1RA, CRP, and TNF-α correlated with BMI and WC; IL-1RA and CRP remained associated after adjustments.
- In men, IL-1RA correlated with BMI and IL-6 with WC.
- Mortality was reduced by low WC/WHR and low inflammation in women, and by high BMI/WC regardless of inflammation in men.
Conclusions:
- Adiposity's impact on mortality in the oldest old is sex-specific when considering inflammatory status.
- Further research is needed to clarify the complex role of adiposity in extreme longevity.
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