Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

CNS Depressants: Alcohol and Nicotine

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...

Toxidromes: Clinical Features

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...

Acid Halides to Esters: Alcoholysis

Acid Halides to Esters: Alcoholysis

Alcoholysis is a nucleophilic acyl substitution reaction in which an alcohol functions as a nucleophile. Acid halides react with alcohol to produce esters. The mechanism proceeds in three steps:

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Mass Spectrometry: Alcohol Fragmentation

Mass Spectrometry: Alcohol Fragmentation

Alcohols (R-OH) ionize to lose one non-bonded electron from the oxygen atom, forming molecular ions. Due to their tendency to fragment rapidly, the intensity of the molecular ion peak in the mass spectrum is weak or sometimes absent. The fragmentation patterns for alcohols occur in two ways, i.e. ⍺-cleavage and dehydration. During ⍺-cleavage, the bond at the ⍺-position adjacent to the hydroxyl group cleaves to give a resonance-stabilized cation and a radical. However, intramolecular dehydration...

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Organization and Management of Critical Care Services: Unexpected Challenges in Leading a Critical Care Organization.

Critical care clinics·2026

Same author

Sedation practices in adult patients with severe ARDS on extracorporeal respiratory support using VV ECMO - An international survey.

Perfusion·2026

Same author

Novel use of negative pressure ventilation for weaning of venovenous extracorporeal membrane oxygenation.

Perfusion·2025

Same author

Late fluid flow in a primitive asteroid revealed by Lu-Hf isotopes in Ryugu.

Nature·2025

Same author

2.2-billion-year-old KREEP-rich volcanism on the Moon.

Science bulletin·2025

Same author

The association of sepsis bundle compliance with mortality in patients with ICU-acquired sepsis: a cohort study.

BMC infectious diseases·2025

Search research articles

Related Experiment Video

Updated: May 18, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Alcohol withdrawal syndrome.

Richard W Carlson¹, Nivedita N Kumar, Edna Wong-Mckinstry

¹Department of Medicine, Maricopa Medical Center, Phoenix, AZ 85008, USA. richardw_carlson@dmgaz.org

Critical Care Clinics

|September 25, 2012

Summary

Alcohol withdrawal syndrome (AWS) complicates other medical conditions in susceptible patients. Severe AWS requires intensive care unit management, posing significant risks for morbidity and death.

More Related Videos

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Related Experiment Videos

Last Updated: May 18, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Area of Science:

Medical Science
Clinical Medicine
Toxicology

Background:

Alcohol withdrawal syndrome (AWS) frequently occurs alongside other medical or surgical issues.
AWS can negatively impact the progression of co-existing health conditions.

Observation:

While AWS mortality has declined, substantial risks for severe illness and death persist.
Complicated management due to various conditions increases patient risk.

Findings:

This review details the clinical scope, history, and pathophysiology of AWS.
It covers clinical presentation and therapeutic strategies for AWS.
Special attention is given to severe AWS cases necessitating intensive care.

Implications:

Understanding AWS is crucial for managing patients with co-occurring disorders.
Effective management, especially in critical care settings, is vital to reduce AWS-related morbidity and mortality.
This review provides a comprehensive overview for clinicians managing AWS.